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ОБНБиохимия Biochemistry

  • ISSN (Print) 0320-9725
  • ISSN (Online) 3034-5294

Механизмы антиоксидантной защиты частиц липопротеидов низкой плотности от свободнорадикального окисления

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Код статьи
S30345294S0320972525010087-1
DOI
10.7868/S3034529425010087
Тип публикации
Статья
Статус публикации
Опубликовано
Авторы
Ланкин В. З.
  • Аффилиация: ФГБУ «Национальный медицинский исследовательский центр кардиологии им. акад. Е.И. Чазова» Минздрава России
Шумаев К. Б.
  • Аффилиация:
    ФГБУ «Национальный медицинский исследовательский центр кардиологии им. акад. Е.И. Чазова» Минздрава России
    ФИЦ Биотехнологии РАН, Институт биохимии имени А.Н. Баха РАН
Медведева В. А.
  • Аффилиация: ФГБУ «Национальный медицинский исследовательский центр кардиологии им. акад. Е.И. Чазова» Минздрава России
Тихазе А. К.
  • Аффилиация: ФГБУ «Национальный медицинский исследовательский центр кардиологии им. акад. Е.И. Чазова» Минздрава России
Коновалова Г. Г.
  • Аффилиация: ФГБУ «Национальный медицинский исследовательский центр кардиологии им. акад. Е.И. Чазова» Минздрава России
Том/ Выпуск
Том 90 / Номер выпуска 1
Страницы
117-130
Аннотация
Установлено, что при введении больным атеросклерозом per os препарата убихинона Q10 (СoQ10) окисленность (содержание липогидропероксидов) частиц липопротеидов низкой плотности (ЛНП) резко снижается, что подтверждает важную роль этого природного антиоксиданта в защите частиц ЛНП от свободнорадикального окисления (СРО) in vivo. Исследовано влияние липофильных природных антиоксидантов убихинола Q10 (СoQ10H2) и α-токоферола (α-ТОН) на кинетические параметры Cu2+-инициированного СРО частиц ЛНП. В этой модельной системе показана возможность синергизма антиоксидантного действия СoQ10H2 и α-ТОН. Обсуждаются вероятные механизмы регенерации липофильных антиоксидантов в частицах ЛНП, в том числе регенерация α-ТОН из токофероксильного радикала (α-ТО•) с участием СoQ10H2 и/или аскорбата.
Ключевые слова
липопротеиды низкой плотности свободнорадикальное окисление антиоксиданты убихинол Q10 α-токоферол биорегенерация антиоксидантов
Дата публикации
04.02.2026
Год выхода
2026
Всего подписок
0
Всего просмотров
86

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