- PII
- S30345294S0320972525040052-1
- DOI
- 10.7868/S3034529425040052
- Publication type
- Article
- Status
- Published
- Authors
- Volume/ Edition
- Volume 90 / Issue number 4
- Pages
- 560-570
- Abstract
- The evolution of proteins from restriction-modification systems containing an endonuclease domain of the RE_AlwI family and either two DNA methyltransferases, each with a domain of the MethyltransfD12 family, or one DNA methyltransferase with two domains of this family was studied. It was found that all such systems recognize one of three DNA sequences, namely GGATC, GATGC or GATGG, and the restriction endonucleases of these systems are divided by sequence similarity into three clades that unambiguously correspond to specificities. The DNA methyltransferase domains of these systems are divided into two groups based on sequence similarity, with two domains of each system belonging to different groups. Within each group, the domains are divided into three clades according to their specificity. Evidence of multiple interspecific horizontal transfers of systems as a whole is found, as well as evidence of gene transfer between systems, including transfer of one of the DNA methyltransferases with a change in specificity. Evolutionary relationships of DNA methyltransferases from such systems with other DNA methyltransferases, including orphan DNA methyltransferases, were revealed.
- Keywords
- система рестрикции-модификации молекулярная эволюция ДНК-метилтрансфераза эндонуклеаза рестрикции горизонтальный перенос генов
- Date of publication
- 26.03.2025
- Year of publication
- 2025
- Number of purchasers
- 0
- Views
- 74
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